Coseal Surgical Sealant
As the go-to synthetic sealant, surgeons rely on Coseal Surgical Sealant during many types of vascular reconstructions. Coseal provides a rapid seal at the suture line, protecting a surgeon’s work during the critical postoperative period and allowing the body time to complete its natural wound healing process.1,2
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Overview
Strong When You Need It
Coseal Surgical Sealant can withstand postoperative spikes over five times normal systolic pressure at up to 660 [+/- 150] mmHg and remains at application site for seven days and is resorbed in 30 days.*2,3
*Preclinical data. Results may not correlate to performance in humans.
Coseal Surgical Sealant: The Clear Choice
Coseal Surgical Sealant has helped achieve adjunct hemostasis for the past 20 years. Hear from Joseph Bavaria, MD on his clinical experience.
Recent Pre-Clinical Study on Surgical Sealants Compares Tissue Reactions
Surgical sealants are commonly used to prevent bleeding following vascular repair and reconstruction, but an adverse response to a tissue sealant could result in poor healing, leading to the need for re-operation. A study published in early 2020 directly compared the aortic and peri-aortic tissue reactions to Coseal Surgical Sealant and BioGlue Surgical Adhesive in a preclinical model.**4
**Pre-clinical data. Results may vary in humans.
Features
Mechanism of Action
Coseal is composed of two biocompatible polyethylene glycols that combine with a dilute hydrogen chloride solution to rapidly form a covalently bonded hydrogel and adhere to both tissue and synthetic graft materials. Learn more about how Coseal works.1
Additional Product Benefits
Independent of the Coagulation Cascade
Coseal works independent of the coagulation cascade, forming a direct mechanical barrier to blood flow regardless of the patient’s coagulation status.2,5
Flexible and Easy to Use
The thin, translucent, motion-response seal supports natural vascular dilation and can be sutured through while allowing for visibility at the suture line.6
Cost Savings and Fewer Complications
In a retrospective study of 102 aortic Bentall procedures, using Coseal as a suture line reinforcement contributed to fewer complications with significant cost savings.5
Coseal Surgical Sealant in Action
Coseal can be dripped or sprayed for both focal and broad application options. Watch the videos to see both spray and drip applications.
Spray Application
Coseal spray application in a left ventricular aneurysm repair
Drip Application
Coseal drip application in a minimally invasive aortic valve replacement
Spray Application
Drip Application
Order & Support
Learn More About Coseal Surgical Sealant
Ordering and Support Information for Coseal Surgical Sealant
Get additional ordering, customer, technical, and medical support information for Coseal Surgical Sealant by contacting Baxter using the links below.
U.S. Catalog
To buy this product, purchase OEM parts and accessories, or look for options and specs please visit U.S. Catalog.
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Other Information
Coseal Surgical Sealant Indications and Important Risk Information
Coseal Surgical Sealant Indications
Coseal Surgical Sealant is indicated for use in vascular reconstructions to achieve adjunctive hemostasis by mechanically sealing areas of leakage.
Important Risk Information for Coseal Surgical Sealant
Coseal Surgical Sealant is not to be used in place of sutures, staples, or mechanical closure.
Coseal Surgical Sealant swells up to four times its volume within 24 hours of application and additional swelling occurs as the gel resorbs. Therefore, surgeons should consider the maximum swell volume and its possible effect on surrounding anatomic structures potentially sensitive to compression.
Apply only as a thin layer.
Use caution when applying with pressurized gas.
Do not place devices or other objects on top of tissue where Coseal Surgical Sealant has been applied, until the material is fully polymerized (non-tacky). Allow at least 60 seconds after application, and before touching or laying any object on top of the Coseal Surgical Sealant.
Do not apply Coseal Surgical Sealant over any devices or objects that will need to be removed. Coseal Surgical Sealant must not be used as a mechanism of adherence, even temporarily, for any object.
Do not inject Coseal Surgical Sealant into vessels.
The safety and performance of Coseal Surgical Sealant have not been established in children and pregnant women.
In vivo testing demonstrated a mild skin sensitization response in an animal model. Similar testing in humans has not been conducted.
Rx only: For safe and proper use of this device, please refer to full device Instructions for Use.
Coseal Surgical Sealant Full Instructions for Use
Disclaimers
Rx only. For safe and proper use of product mentioned herein, please refer to the Instructions for Use or Operator Manual.
Baxter, Coseal, Floseal, PerClot and Preveleak are trademarks of Baxter International Inc. or its subsidiaries. Any other trademarks, product names or brand images are the property of their respective owners.
References
- Coseal Surgical Sealant Instructions for Use 2018, Hayward, CA: Baxter Healthcare Corporation. March 2009.
- Hill A, Estridge TD, Maroney M, et al. Treatment of suture line bleeding with a novel synthetic surgical sealant in a canine iliac PTFE graft model. J Biomed. 2001;58: 308-312.
- Wallace DG, Cruise GM, Rhee WM, et al. A tissue sealant based on reactive multifunctional polyethylene glycol. J Biomed. 2001;58: 545-555.
- Slezak, Paul, et al. Tissue reactions to PEG and glutaraldehyde-based surgical sealants in a rabbit aorta model. Journal of Biomaterials, 2020, 0(0) 1-11.
- Natour E, Suedkamp M, Dapunt OE. Assessment on the effect of blood loss and transfusion requirements when adding a polyethylene glycol sealant to the anastomotic closure of aortic procedures: a case-control analysis of 102 patients undergoing Bentall procedures. J Cardiothorac Surg. 2012;7:105.
- DeAnda A, Jr., Elefteriades JA, Hasaniya NW, Lattouf OM, Lazzara RR. Improving outcomes through the use of surgical sealants for anastomotic sealing during cardiovascular surgery. J Card Surg. 2009;24(3):325-333.